Combination screen in multi-cell type tumor spheroids reveals interaction between aryl hydrocarbon receptor antagonists and E1 ubiquitin-activating enzyme inhibitor

Combination screen in multi-cell type tumor spheroids reveals interaction between aryl hydrocarbon receptor antagonists and E1 ubiquitin-activating enzyme inhibitor

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates genes of drug transporters and metabolic enzymes to detoxify small molecule xenobiotics. It has a complex role in cancer biology, influencing both the progression and suppression of tumors by modulating mal...

书目详细资料
Main Authors:	Thomas S. Dexheimer, Nathan P. Coussens, Thomas Silvers, Eric M. Jones, Li Chen, Jianwen Fang, Joel Morris, Jeffrey A. Moscow, James H. Doroshow, Beverly A. Teicher
格式:	文件
语言:	English
出版:	Elsevier 2024-10-01
丛编:	SLAS Discovery
主题:	Spheroids Drug combination Aryl hydrocarbon receptor
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2472555224000480

相似书籍

Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids
由: Thomas S. Dexheimer, et al.
出版: (2025-04-01)

Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor
由: Xiaoyu Xi, et al.
出版: (2022-03-01)

Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist
由: Gulsum E. Muku, et al.
出版: (2018-11-01)

Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss
由: Paulo Müller Ramos, et al.
出版: (2017-06-01)

Aryl hydrocarbon receptor controls regulatory CD4+T cell function
由: Caroline Pot
出版: (2012-05-01)

Molecular Docking Study of Flavonoids to Block the Aryl Hydrocarbon Receptor
由: Oscar Collado García, et al.
出版: (2021-11-01)

Influence of Simvastatin and Interleukin 1 Receptor Antagonist on Expression of Aryl Hydrocarbon Receptors Under Experimental Acute Ileitis
由: O.S. Zherebiatiev, et al.
出版: (2015-02-01)

Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands
由: Paul J. Wisniewski, et al.
出版: (2021-03-01)

Aryl Hydrocarbon Receptor as an Anticancer Target: An Overview of Ten Years Odyssey
由: Hamza Hanieh, et al.
出版: (2023-05-01)

Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury
由: Michelle M Lissner, et al.
出版: (2020-10-01)

The aryl hydrocarbon receptor as a model PAS sensor
由: Emmanuel Vazquez-Rivera, et al.
出版: (2022-01-01)

Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression
由: Claudia Rejano-Gordillo, et al.
出版: (2022-04-01)

An Increased Level of Aryl Hydrocarbon Receptor in Patients with Pancreatic Cancer
由: Sahar Masoudi, et al.
出版: (2019-01-01)

Therapeutic Potential of Nutritional Aryl Hydrocarbon Receptor Ligands in Gut-Related Inflammation and Diseases
由: Fu-Chen Huang
出版: (2024-12-01)

The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages
由: Ann-Marie Maier, et al.
出版: (2023-04-01)

Characterization of marine-derived halogenated indoles as ligands of the aryl hydrocarbon receptor
由: Jessie King, et al.
出版: (2022-01-01)

Corrigendum: The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages
由: Ann-Marie Maier, et al.
出版: (2023-06-01)

Staphylococcus aureus Activates the Aryl Hydrocarbon Receptor in Human Keratinocytes
由: Eva-Lena Stange, et al.
出版: (2022-05-01)

The role of aryl hydrocarbon receptor in vitiligo: a review
由: Yiting Li, et al.
出版: (2024-02-01)

Differential Regulation of the Asthmatic Phenotype by the Aryl Hydrocarbon Receptor
由: Hussein Traboulsi, et al.
出版: (2021-10-01)

Role of aryl hydrocarbon receptor in toxic effects of emerging environmental pollutants
由: Mingxuan ZHANG, et al.
出版: (2024-12-01)

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells
由: Jian Ye, et al.
出版: (2017-11-01)

Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration
由: Adeline Cros, et al.
出版: (2023-05-01)

NEW TRENDS IN ARYL HYDROCARBON RECEPTOR BIOLOGY
由: Pedro M. Fernández-Salguero, et al.
出版: (2016-05-01)

The Aryl Hydrocarbon Receptor and Tumor Immunity
由: Ping Xue, et al.
出版: (2018-02-01)

The potential of aryl hydrocarbon receptor as receptors for metabolic changes in tumors
由: Zhiying Wang, et al.
出版: (2024-02-01)

Expression and role of aryl hydrocarbon receptor in Aspergillus fumigatus keratitis
由: Li Zhang, et al.
出版: (2020-02-01)

Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor
由: Alba De Juan, et al.
出版: (2021-05-01)

The Antioxidant Drug Edaravone Binds to the Aryl Hydrocarbon Receptor (AHR) and Promotes the Downstream Signaling Pathway Activation
由: Caterina Veroni, et al.
出版: (2024-04-01)

Gene-environment interactions in male reproductive health: special reference to the aryl hydrocarbon receptor signaling pathway
由: Leon J S Brokken, et al.
出版: (2014-02-01)

Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases
由: Maddalena Napolitano, et al.
出版: (2021-12-01)

The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function
由: Robin Park, et al.
出版: (2020-10-01)

Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA
由: Mohammad Taghi Palizgir, et al.
出版: (2017-10-01)

The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses
由: Christoph F.A. Vogel, et al.
出版: (2020-07-01)

Effect of Probiotics on Gastrointestinal Health Through the Aryl Hydrocarbon Receptor Pathway: A Systematic Review
由: Adrián De la Rosa González, et al.
出版: (2024-10-01)

Maternal consumption of yoghurt activating the aryl hydrocarbon receptor increases group 3 innate lymphoid cells in murine offspring
由: Grégory Pimentel, et al.
出版: (2024-12-01)

The Aryl Hydrocarbon Receptor as an Immune-Modulator of Atmospheric Particulate Matter-Mediated Autoimmunity
由: Chelsea A. O'Driscoll, et al.
出版: (2018-12-01)

Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor
由: Nicholas Dopkins, et al.
出版: (2021-01-01)

Rutaecarpine Inhibits U87 Glioblastoma Cell Migration by Activating the Aryl Hydrocarbon Receptor Signaling Pathway
由: Yiyun Liu, et al.
出版: (2021-12-01)

Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation
由: Yan-Heng Zhou, et al.
出版: (2019-12-01)