Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity

Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity

Abstract Background Necroptosis is a form of regulated necrosis that is involved in various autoimmune diseases. Mixed lineage kinase domain-like pseudokinase (MLKL) has been identified as a key executor of necroptosis; however, the significance of MLKL in peripheral blood mononuclear cells (PBMCs)...

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Bibliographic Details
Main Authors: Mingjiao Zhang, Hongyu Jie, Yong Wu, Xinai Han, Xing Li, Yi He, Xingliang Shi, Yuwei Luo, Ying Sun, Jinlong Yang, Jing Yang, Shulv Quan, Xiaobin Lao, Liping Tan, Erwei Sun
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Arthritis Research & Therapy
Subjects:
SLE
Necroptosis
MLKL
mRNA
PBMCs
Diagnosis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02332-7

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http://link.springer.com/article/10.1186/s13075-020-02332-7

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