Intranasal Administration of <i>N</i>-acetyl-<span style="font-variant: small-caps">L</span>-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Intranasal Administration of <i>N</i>-acetyl-<span style="font-variant: small-caps">L</span>-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently delivers drugs to the brain and exhibits excellent...

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Bibliographic Details
Main Authors: Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
nose-to-brain
nanocarrier
neurodegeneration
spinal cord
<i>N</i>-acetyl-<span style="font-variant: small-caps">L</span>-cysteine
Online Access:https://www.mdpi.com/1999-4923/14/12/2590

Internet

https://www.mdpi.com/1999-4923/14/12/2590

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