Dock4 is required for the maintenance of cochlear hair cells and hearing function

Dock4 is required for the maintenance of cochlear hair cells and hearing function

Auditory hair cells (HCs) are the mechanosensory receptors of the cochlea, and HC loss or malfunction can result from genetic defects. Dock4, a member of the Dock180-related protein superfamily, is a guanine nucleotide exchange factor for Rac1, and previous reports have shown that Dock4 mutations ar...

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Bibliographic Details
Main Authors: Guodong Hong, Xiaolong Fu, Jieyu Qi, Buwei Shao, Xuan Han, Yuan Fang, Shuang Liu, Cheng Cheng, Chengwen Zhu, Junyan Gao, Xia Gao, Jie Chen, Ming Xia, Wei Xiong, Renjie Chai
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2023-07-01
Series:Fundamental Research
Subjects:
Hair cell
Stereocilia
Oxidative stress
Apoptosis
Hearing loss
Dock4
Online Access:http://www.sciencedirect.com/science/article/pii/S2667325822001996

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http://www.sciencedirect.com/science/article/pii/S2667325822001996

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