TNFα Mediates Inflammation-Induced Effects on <i>PPARG</i> Splicing in Adipose Tissue and Mesenchymal Precursor Cells

TNFα Mediates Inflammation-Induced Effects on <i>PPARG</i> Splicing in Adipose Tissue and Mesenchymal Precursor Cells

Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in the AT of obese/diabetic patients able to impair adipocyte...

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Bibliographic Details
Main Authors: Simona Cataldi, Marianna Aprile, Daniela Melillo, Inès Mucel, Sophie Giorgetti-Peraldi, Mireille Cormont, Paola Italiani, Matthias Blüher, Jean-François Tanti, Alfredo Ciccodicola, Valerio Costa
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
<i>PPARG</i> splicing
dominant negative isoform
inflammation
TNFα
adipocyte precursors
hypertrophic obesity
Online Access:https://www.mdpi.com/2073-4409/11/1/42

Internet

https://www.mdpi.com/2073-4409/11/1/42

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