Auditory and Vestibular Characteristics of NLRP3 Inflammasome Related Autoinflammatory Disorders: Monogenic Hearing Loss Can Be Improved by Anti-interleukin-1 Therapy

Auditory and Vestibular Characteristics of NLRP3 Inflammasome Related Autoinflammatory Disorders: Monogenic Hearing Loss Can Be Improved by Anti-interleukin-1 Therapy

Inflammasomes are large multimeric protein complexes which regulate the activation of the proinflammatory cytokines interleukins-1β and−18 and inflammatory cell death called pyroptosis. NLRP1, NLRP3, NLRC4, AIM2, and pyrin can induce the formation of inflammasomes. Of these, the NLRP3 inflammasome i...

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Bibliographic Details
Main Authors: Hiroshi Nakanishi, Satoshi Yamada, Junya Kita, Daichi Shinmura, Kumiko Hosokawa, Sosuke Sahara, Kiyoshi Misawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Neurology
Subjects:
NLRP3
inflammasome
cryopyrin-associated periodic syndrome
hearing loss
DFNA34
anakinra
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.865763/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.865763/full

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