Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis

Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis

Background: Ischemic stroke seriously threatens human health because of high rates of morbidity, mortality and disability. This study compared the effects of nicotinamide adenine dinucleotide (NAD+) and butylphthalide (NBP) on in vitro and in vivo ischemic stroke models.Methods: Transient middle cer...

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Bibliographic Details
Main Authors: Xin-Xin Wang, Guang-Hui Mao, Qi-Qi Li, Jie Tang, Hua Zhang, Kang-Lin Wang, Lei Wang, Hong Ni, Rui Sheng, Zheng-Hong Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
NAD+
NBP
cerebral ischemia-reperfusion
mitochondria
SIRT3
SIRT1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1096533/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1096533/full

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