Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia

Abstract Background Microglia are innate immune cells that are the only residential macrophages in the central nervous system. They play vital physiological roles in the adult brain and during development. Microglia are particularly in the spotlight because many genetic risk factors recently identif...

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Bibliographic Details
Main Authors: Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe, Hideyuki Okano
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Inflammation and Regeneration
Subjects:
Online Access:https://doi.org/10.1186/s41232-022-00201-1