Contribution of TLR4 signaling in intermittent hypoxia-mediated atherosclerosis progression

Contribution of TLR4 signaling in intermittent hypoxia-mediated atherosclerosis progression

Abstract Background Intermittent hypoxia (IH), a typical character of obstructive sleep apnea (OSA), is related to atherogenesis. However, the role of IH on atherosclerosis (AS) progression and the mechanisms involved remains poorly understood. Methods In the present study, high-fat fed ApoE−/− mice...

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Bibliographic Details
Main Authors: Xianqin Zeng, Rong Guo, Mei Dong, Julia Zheng, Huili Lin, Huixia Lu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Translational Medicine
Subjects:
Atherosclerosis
Intermittent hypoxia
Toll-like receptor 4
Nuclear factor κappa B
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12967-018-1479-6

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http://link.springer.com/article/10.1186/s12967-018-1479-6

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