Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Fibrosis of the skin plays an important role in scleroderma. Here the authors demonstrate genetic and epigenetic abnormalities at the centromere that affect the replication of the chromosomes, resulting in activation of pathways involved in inflammation and fibrosis

Bibliographic Details
Main Authors: Souren Paul, Mark H. Kaplan, Dinesh Khanna, Preston M. McCourt, Anjan K. Saha, Pei-Suen Tsou, Mahek Anand, Alexander Radecki, Mohamad Mourad, Amr H. Sawalha, David M. Markovitz, Rafael Contreras-Galindo
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34775-8

Internet

https://doi.org/10.1038/s41467-022-34775-8

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