Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
Fibrosis of the skin plays an important role in scleroderma. Here the authors demonstrate genetic and epigenetic abnormalities at the centromere that affect the replication of the chromosomes, resulting in activation of pathways involved in inflammation and fibrosis
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34775-8 |
| _version_ | 1797984099958259712 |
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| author | Souren Paul Mark H. Kaplan Dinesh Khanna Preston M. McCourt Anjan K. Saha Pei-Suen Tsou Mahek Anand Alexander Radecki Mohamad Mourad Amr H. Sawalha David M. Markovitz Rafael Contreras-Galindo |
| author_facet | Souren Paul Mark H. Kaplan Dinesh Khanna Preston M. McCourt Anjan K. Saha Pei-Suen Tsou Mahek Anand Alexander Radecki Mohamad Mourad Amr H. Sawalha David M. Markovitz Rafael Contreras-Galindo |
| author_sort | Souren Paul |
| collection | DOAJ |
| description | Fibrosis of the skin plays an important role in scleroderma. Here the authors demonstrate genetic and epigenetic abnormalities at the centromere that affect the replication of the chromosomes, resulting in activation of pathways involved in inflammation and fibrosis |
| first_indexed | 2024-04-11T06:57:14Z |
| format | Article |
| id | doaj.art-d5eaf6cdd6504e8d8ebc8070af2ffb48 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T06:57:14Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d5eaf6cdd6504e8d8ebc8070af2ffb482022-12-22T04:39:01ZengNature PortfolioNature Communications2041-17232022-11-0113111610.1038/s41467-022-34775-8Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosisSouren Paul0Mark H. Kaplan1Dinesh Khanna2Preston M. McCourt3Anjan K. Saha4Pei-Suen Tsou5Mahek Anand6Alexander Radecki7Mohamad Mourad8Amr H. Sawalha9David M. Markovitz10Rafael Contreras-Galindo11The Hormel Institute, University of MinnesotaDepartment of Internal Medicine, University of MichiganDepartment of Internal Medicine, University of MichiganThe Hormel Institute, University of MinnesotaDepartment of Internal Medicine, University of MichiganDepartment of Internal Medicine, University of MichiganThe Hormel Institute, University of MinnesotaDepartment of Internal Medicine, University of MichiganDepartment of Internal Medicine, University of MichiganDepartment of Internal Medicine, University of MichiganDepartment of Internal Medicine, University of MichiganThe Hormel Institute, University of MinnesotaFibrosis of the skin plays an important role in scleroderma. Here the authors demonstrate genetic and epigenetic abnormalities at the centromere that affect the replication of the chromosomes, resulting in activation of pathways involved in inflammation and fibrosishttps://doi.org/10.1038/s41467-022-34775-8 |
| spellingShingle | Souren Paul Mark H. Kaplan Dinesh Khanna Preston M. McCourt Anjan K. Saha Pei-Suen Tsou Mahek Anand Alexander Radecki Mohamad Mourad Amr H. Sawalha David M. Markovitz Rafael Contreras-Galindo Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis Nature Communications |
| title | Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis |
| title_full | Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis |
| title_fullStr | Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis |
| title_full_unstemmed | Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis |
| title_short | Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis |
| title_sort | centromere defects chromosome instability and cgas sting activation in systemic sclerosis |
| url | https://doi.org/10.1038/s41467-022-34775-8 |
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