Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents

Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents

A series of phenylbipyridinylpyrazoles was synthesized through the reaction of 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (4) with different 6-substituted pyridine-3-ylboronic acids. The final compounds 5a–j were screened at 10 µM against over 60 tumor cel...

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Bibliographic Details
Main Authors: Mohammad M. Al-Sanea, Ahmed Elkamhawy, Ahmed Zakaria, Byung Sun Park, Youngjoo Kwon, So Ha Lee, Sang Woo Lee, In Tae Kim
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
cancer
cell lines
phenylbipyridinylpyrazole
antiproliferative agents
COMPARE analysis
Online Access:http://www.mdpi.com/1420-3049/20/1/1031

Internet

http://www.mdpi.com/1420-3049/20/1/1031

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