MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients

MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients

Rett syndrome (RTT) is a severe and rare neurological disorder that is caused by mutations in the X-linked MECP2 (methyl CpG-binding protein 2) gene. MeCP2 protein is an important epigenetic factor in the brain and in neurons. In Mecp2-deficient neurons, nucleoli structures are compromised. Nucleoli...

Full description

Bibliographic Details
Main Authors: Carl O. Olson, Shervin Pejhan, Daniel Kroft, Kimia Sheikholeslami, David Fuss, Marjorie Buist, Annan Ali Sher, Marc R. Del Bigio, Yehezkel Sztainberg, Victoria Mok Siu, Lee Cyn Ang, Marianne Sabourin-Felix, Tom Moss, Mojgan Rastegar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Genetics
Subjects:
MECP2 mutations
Rett syndrome
human brain tissues
DNA methylation
ribosome biogenesis
mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00635/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00635/full

Similar Items