Mebendazole Inhibits <i>Histoplasma capsulatum</i> In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels

Mebendazole Inhibits <i>Histoplasma capsulatum</i> In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels

Histoplasmosis is a frequent mycosis in people living with HIV/AIDS and other immunocompromised hosts. Histoplasmosis has high rates of mortality in these patients if treatment is unsuccessful. Itraconazole and amphotericin B are used to treat histoplasmosis; however, both antifungals have potential...

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Bibliographic Details
Main Authors: Marcos Abreu Almeida, Andrea Reis Bernardes-Engemann, Rowena Alves Coelho, Camila Jantoro Guzman Lugones, Iara Bastos de Andrade, Dario Corrêa-Junior, Simone Santiago Carvalho de Oliveira, André Luis Souza dos Santos, Susana Frases, Márcio Lourenço Rodrigues, Richard Hemmi Valente, Rosely Maria Zancopé-Oliveira, Rodrigo Almeida-Paes
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Journal of Fungi
Subjects:
antifungal activity
benzimidazole
drug repurposing
histoplasmosis
proteomics
Online Access:https://www.mdpi.com/2309-608X/9/3/385

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https://www.mdpi.com/2309-608X/9/3/385

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