Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism

Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism

Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf‐16. To uncover regulatory mechanisms coordinating this...

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Bibliographic Details
Main Authors: Gerdine J Stout, Edwin C A Stigter, Paul B Essers, Klaas W Mulder, Annemieke Kolkman, Dorien S Snijders, Niels J F van den Broek, Marco C Betist, Hendrik C Korswagen, Alyson W MacInnes, Arjan B Brenkman
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:Molecular Systems Biology
Subjects:
ageing
high‐throughput analysis
metabolism
protein metabolism
translation
Online Access:https://doi.org/10.1038/msb.2013.35

Internet

https://doi.org/10.1038/msb.2013.35

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