Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism
Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf‐16. To uncover regulatory mechanisms coordinating this...
Main Authors: | Gerdine J Stout, Edwin C A Stigter, Paul B Essers, Klaas W Mulder, Annemieke Kolkman, Dorien S Snijders, Niels J F van den Broek, Marco C Betist, Hendrik C Korswagen, Alyson W MacInnes, Arjan B Brenkman |
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Format: | Article |
Language: | English |
Published: |
Springer Nature
2013-01-01
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Series: | Molecular Systems Biology |
Subjects: | |
Online Access: | https://doi.org/10.1038/msb.2013.35 |
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