CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

Abstract Vascular cell functionality is critical to blood vessel homeostasis. Constitutive NF-κB activation in vascular cells results in chronic vascular inflammation, leading to various cardiovascular diseases. However, how NF-κB regulates human blood vessel homeostasis remains largely elusive. Her...

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Bibliographic Details
Main Authors: Ping Wang, Zunpeng Liu, Xiaoqian Zhang, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi Song, Jing Qu
Format: Article
Language:English
Published: Oxford University Press 2018-07-01
Series:Protein & Cell
Subjects:
NF-κB
RelA
Stem cell
Inflammation
Apoptosis
Online Access:http://link.springer.com/article/10.1007/s13238-018-0560-5

Internet

http://link.springer.com/article/10.1007/s13238-018-0560-5

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