Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated that the SIRT/BRCA1 synthetic lethality was reversed...

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Bibliographic Details
Main Authors: Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02770-2

Internet

https://doi.org/10.1038/s42003-021-02770-2

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