Wentilactone A Reverses the NF-κB/ECM1 Signaling-Induced Cisplatin Resistance through Inhibition of IKK/IκB in Ovarian Cancer Cells

Wentilactone A Reverses the NF-κB/ECM1 Signaling-Induced Cisplatin Resistance through Inhibition of IKK/IκB in Ovarian Cancer Cells

Wentilactone A (WA) is a tetranorditerpenoid isolated from marine algae. We previously found that WA inhibited cancer cell proliferation with little toxicity. In this study, we show that high expression of extracellular matrix protein-1 (ECM1) promotes cancer cell cisplatin resistance, and the secre...

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Bibliographic Details
Main Authors: Cuiting Lv, Chunxia Ren, Yinjue Yu, Huijing Yin, Caiguo Huang, Gong Yang, Yang Hong
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Nutrients
Subjects:
NF-κB/ECM1
tumor microenvironment
cisplatin resistance
wentilactone A
ovarian cancer
Online Access:https://www.mdpi.com/2072-6643/14/18/3790

Internet

https://www.mdpi.com/2072-6643/14/18/3790

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