COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

Summary: Background: In the aftermath of Covid-19, some patients develop a fibrotic lung disease, i.e., post-COVID-19 lung disease (PCLD), for which we currently lack insights into pathogenesis, disease models, or treatment options. Methods: Using an AI-guided approach, we analyzed > 1000 human...

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Bibliographic Details
Main Authors: Saptarshi Sinha, Vanessa Castillo, Celia R. Espinoza, Courtney Tindle, Ayden G. Fonseca, Jennifer M. Dan, Gajanan D. Katkar, Soumita Das, Debashis Sahoo, Pradipta Ghosh
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
Artificial intelligence/machine learning
Immune response
Alveolar type II pneumocytes
Damage-associated transient progenitor (DATP)
Senescence
ER-stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003668

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http://www.sciencedirect.com/science/article/pii/S2352396422003668

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