Adenosine monophosphate deaminase in the endoplasmic reticulum–mitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts

Adenosine monophosphate deaminase in the endoplasmic reticulum–mitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts

Abstract Aims/Introduction We previously showed that upregulation of myocardial adenosine monophosphate deaminase (AMPD) is associated with pressure overload‐induced diastolic dysfunction in type 2 diabetes hearts. Here, we examined involvement of AMPD localized in the endoplasmic reticulum–mitochon...

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Bibliographic Details
Main Authors: Arata Osanami, Tatsuya Sato, Yuki Toda, Masaki Shimizu, Atsushi Kuno, Hidemichi Kouzu, Toshiyuki Yano, Wataru Ohwada, Toshifumi Ogawa, Tetsuji Miura, Masaya Tanno
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of Diabetes Investigation
Subjects:
Adenosine monophosphate deaminase
Diabetic cardiomyopathy
Mitochondria‐associated endoplasmic reticulum membrane
Online Access:https://doi.org/10.1111/jdi.13982

Internet

https://doi.org/10.1111/jdi.13982

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