Circulating tumor-associated antigen-specific IFNγ+4-1BB+ CD8+ T cells as peripheral biomarkers of treatment outcomes in patients with pancreatic cancer

Circulating tumor-associated antigen-specific IFNγ+4-1BB+ CD8+ T cells as peripheral biomarkers of treatment outcomes in patients with pancreatic cancer

CD8+ T cells affect the outcomes of pancreatic ductal adenocarcinoma (PDAC). Using tissue samples at pre-treatment to monitor the immune response is challenging, while blood samples are beneficial in overcoming this limitation. In this study, we measured peripheral antigen-specific CD8+ T cell respo...

Full description

Bibliographic Details
Main Authors: Hirotomo Murakami, Shokichi Takahama, Hirofumi Akita, Shogo Kobayashi, Yuji Masuta, Yuta Nagatsuka, Masaya Higashiguchi, Akira Tomokuni, Keiichi Yoshida, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi, Nariaki Matsuura, Takuya Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
pancreatic cancer
tumor-associated antigen-specific CD8 + T cells
PBMC
prognostic marker
immune checkpoint inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1363568/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1363568/full

Similar Items