Unprecedented effect of vitamin D3 on T-cell receptor beta subunit and alpha7 nicotinic acetylcholine receptor expression in a 3-nitropropionic acid induced mouse model of Huntington’s disease

Unprecedented effect of vitamin D3 on T-cell receptor beta subunit and alpha7 nicotinic acetylcholine receptor expression in a 3-nitropropionic acid induced mouse model of Huntington’s disease

Introduction: 3-NP induction in rodent models has been shown to induce selective neurodegeneration in the striatum followed by the cortex (Brouillet, 2014). However, it remains unclear whether, under such a neurotoxic condition, characterized by neuroinflammation and oxidative stress, the gene expre...

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Bibliographic Details
Main Authors: SKV Manjari, Sharon Mariam Abraham, R. Poornima, Rajneesh Kumar Chaturvedi, Shuvadeep Maity, Pragya Komal
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:IBRO Neuroscience Reports
Subjects:
T-cell receptor-beta subunit (TCR- β)
Huntington’s disease (HD)
Immune receptors
α7 nicotinic acetylcholine receptors (α7 nAChRs)
Vitamin D3 (VD)
Nuclear factor kappa B (NF-κB)
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242123000581

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http://www.sciencedirect.com/science/article/pii/S2667242123000581

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