Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination

Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination

Three-dimensional reconstruction of the electron-scattering potential of biological macromolecules from electron cryo-microscopy (cryo-EM) projection images is an ill-posed problem. The most popular cryo-EM software solutions to date rely on a regularization approach that is based on the prior assum...

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Bibliographic Details
Main Authors: Dari Kimanius, Gustav Zickert, Takanori Nakane, Jonas Adler, Sebastian Lunz, Carola-Bibiane Schönlieb, Ozan Öktem, Sjors H. W. Scheres
Format: Article
Language:English
Published: International Union of Crystallography 2021-01-01
Series:IUCrJ
Subjects:
3d reconstruction
image processing
single-particle cryo-em
imaging
structure determination
cryo-electron microscopy
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252520014384

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http://scripts.iucr.org/cgi-bin/paper?S2052252520014384

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