Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model

Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model

Epithelial-mesenchymal transition (EMT) is currently recognized as the main cellular event that contributes to airway remodeling. Eosinophils can induce EMT in airway epithelial cells via increased transforming growth factor (TGF)-β production. We assessed the effect of synthetic 2,4,6-trihydroxy-3-...

Full description

Bibliographic Details
Main Authors: Yu Z. Lee, Hui M. Yap, Khozirah Shaari, Chau L. Tham, Mohd R. Sulaiman, Daud A. Israf
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
geranyl acetophenone
epithelial-mesenchymal transition
transforming growth factor beta
airway remodeling
asthma
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00837/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00837/full

Similar Items