Elucidation and Regulation of Tyrosine Kinase Inhibitor Resistance in Renal Cell Carcinoma Cells from the Perspective of Glutamine Metabolism

Elucidation and Regulation of Tyrosine Kinase Inhibitor Resistance in Renal Cell Carcinoma Cells from the Perspective of Glutamine Metabolism

Tyrosine kinase inhibitors (TKIs) play a crucial role in the treatment of advanced renal cell carcinoma (RCC). However, there is a lack of useful biomarkers for assessing treatment efficacy. Through urinary metabolite analysis, we identified the metabolites and pathways involved in TKI resistance an...

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Bibliographic Details
Main Authors: Kento Morozumi, Yoshihide Kawasaki, Tomonori Sato, Masamitsu Maekawa, Shinya Takasaki, Shuichi Shimada, Takanari Sakai, Shinichi Yamashita, Nariyasu Mano, Akihiro Ito
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Metabolites
Subjects:
glutamine metabolism
PTEN
renal cell carcinoma
TKI resistance
VEGFR
VEGF signaling
Online Access:https://www.mdpi.com/2218-1989/14/3/170

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https://www.mdpi.com/2218-1989/14/3/170

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