Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models

Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models

To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and MCR). Gimatecan was significantly more effect...

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Bibliographic Details
Main Authors: Paola Ulivi, Wainer Zoli, Francesco Fabbri, Giovanni Brigliadori, Luca Ricotti, Anna Tesei, Marco Rosetti, Michelandrea De Cesare, Giovanni L. Beretta, Elisabetta Corna, Rosanna Supino, Franco Zunino
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Bladder carcinoma
DNA topoisomerase I
gimatecan
camptothecins
antitumor activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800168

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http://www.sciencedirect.com/science/article/pii/S1476558605800168

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