Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats
The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fl...
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MDPI AG
2010-08-01
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| Series: | Molecules |
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| author | Tariq Al-Qirim Moyad Shahwan Waseem El-Huneidi Yusuf Al-Hiari Ghassan Shattat Ghassan Abu Sheikha Rania Al-Qirim |
| author_facet | Tariq Al-Qirim Moyad Shahwan Waseem El-Huneidi Yusuf Al-Hiari Ghassan Shattat Ghassan Abu Sheikha Rania Al-Qirim |
| author_sort | Tariq Al-Qirim |
| collection | DOAJ |
| description | The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N-(4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role. |
| first_indexed | 2024-12-14T04:44:32Z |
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| id | doaj.art-d60dc9c2db4e4b26ae5d07a1336ee658 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T04:44:32Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d60dc9c2db4e4b26ae5d07a1336ee6582022-12-21T23:16:43ZengMDPI AGMolecules1420-30492010-08-011595840584910.3390/molecules15095840Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic RatsTariq Al-QirimMoyad ShahwanWaseem El-HuneidiYusuf Al-HiariGhassan ShattatGhassan Abu SheikhaRania Al-QirimThe lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N-(4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.http://www.mdpi.com/1420-3049/15/9/5840/Triton WR-1339-induced hyperlipidemic ratsN-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamideshigh-density lipoprotein-cholesteroltriglycerideshypolipidemic activity |
| spellingShingle | Tariq Al-Qirim Moyad Shahwan Waseem El-Huneidi Yusuf Al-Hiari Ghassan Shattat Ghassan Abu Sheikha Rania Al-Qirim Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats Molecules Triton WR-1339-induced hyperlipidemic rats N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides high-density lipoprotein-cholesterol triglycerides hypolipidemic activity |
| title | Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_full | Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_fullStr | Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_full_unstemmed | Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_short | Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_sort | synthesis and anti hyperlipidemic evaluation of n benzoylphenyl 5 fluoro 1h indole 2 carboxamide derivatives in triton wr 1339 induced hyperlipidemic rats |
| topic | Triton WR-1339-induced hyperlipidemic rats N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides high-density lipoprotein-cholesterol triglycerides hypolipidemic activity |
| url | http://www.mdpi.com/1420-3049/15/9/5840/ |
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