Synthesis and In Vitro Antitumor Activity Evaluation of Gefitinib-1,2,3-Triazole Derivatives

Synthesis and In Vitro Antitumor Activity Evaluation of Gefitinib-1,2,3-Triazole Derivatives

In this study, 14 structurally novel gefitinib-1,2,3-triazole derivatives were synthesized using a click chemistry approach and characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR and high-resolution mass spectrometry (HRMS). Preliminary cell counting kit-8 results showed...

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Bibliographic Details
Main Authors: Zijun Liu, Jiancheng Liu, En Gao, Longfei Mao, Shu Hu, Sanqiang Li
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
gefitinib
1,2,3-triazole
antitumor drug
cell apoptosis
cell migration
Online Access:https://www.mdpi.com/1420-3049/29/4/837

Internet

https://www.mdpi.com/1420-3049/29/4/837

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