Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP

Objective: MEHP, as the metabolite of DEHP, is a widely used environmental endocrine disruptor. Ovarian granulosa cells participate in maintaining the function of ovary and COX2/PGE2 pathway may regulate the function of granulosa cells. We aimed to explore how COX-2/PGE2 pathway affects cell apoptos...

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Bibliographic Details
Main Authors: Xu Li, Ying Zhu, Tianyang Zhao, Xueting Zhang, Honghao Qian, Jia Wang, Xiaohan Miao, Liting Zhou, Na Li, Lin Ye
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132300221X