Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films
In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the mill...
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| Format: | Article |
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MDPI AG
2018-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/10/4/222 |
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| author | Alessandra Adrover Gabriele Varani Patrizia Paolicelli Stefania Petralito Laura Di Muzio Maria Antonietta Casadei Ingunn Tho |
| author_facet | Alessandra Adrover Gabriele Varani Patrizia Paolicelli Stefania Petralito Laura Di Muzio Maria Antonietta Casadei Ingunn Tho |
| author_sort | Alessandra Adrover |
| collection | DOAJ |
| description | In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the millifluidic flow-through device, and the paddle type dissolution apparatus (USP II). In order to enable drug incorporation within HPMC films, a multifunctional excipient, hydroxypropyl-<inline-formula> <math display="inline"> <semantics> <mi>β</mi> </semantics> </math> </inline-formula>-cyclodextrin (HP-<inline-formula> <math display="inline"> <semantics> <mi>β</mi> </semantics> </math> </inline-formula>-CD) has been included in the formulation, and the influence of HP-<inline-formula> <math display="inline"> <semantics> <mi>β</mi> </semantics> </math> </inline-formula>-CD on film swelling, erosion, and release properties has been investigated. Mathematical models capable of describing the swelling and release processes from HPMC erodible thin films in different apparatuses have been developed. In particular, we propose a new model for the description of drug transport and release in a Franz cell that accounts for the effect of the unavoidable imperfect mixing of the receptor chamber. |
| first_indexed | 2024-04-11T12:54:27Z |
| format | Article |
| id | doaj.art-d61076e5e6894309bda2916142545581 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T12:54:27Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d61076e5e6894309bda29161425455812022-12-22T04:23:06ZengMDPI AGPharmaceutics1999-49232018-11-0110422210.3390/pharmaceutics10040222pharmaceutics10040222Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin FilmsAlessandra Adrover0Gabriele Varani1Patrizia Paolicelli2Stefania Petralito3Laura Di Muzio4Maria Antonietta Casadei5Ingunn Tho6Dipartimento di Ingegneria Chimica, Materiali e Ambiente, Sapienza Universitá di Roma, Via Eudossiana 18, 00184 Rome, ItalyDipartimento di Ingegneria Chimica, Materiali e Ambiente, Sapienza Universitá di Roma, Via Eudossiana 18, 00184 Rome, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, ItalyDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, ItalySection of Pharmaceutics and Social Pharmacy, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, NorwayIn this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the millifluidic flow-through device, and the paddle type dissolution apparatus (USP II). In order to enable drug incorporation within HPMC films, a multifunctional excipient, hydroxypropyl-<inline-formula> <math display="inline"> <semantics> <mi>β</mi> </semantics> </math> </inline-formula>-cyclodextrin (HP-<inline-formula> <math display="inline"> <semantics> <mi>β</mi> </semantics> </math> </inline-formula>-CD) has been included in the formulation, and the influence of HP-<inline-formula> <math display="inline"> <semantics> <mi>β</mi> </semantics> </math> </inline-formula>-CD on film swelling, erosion, and release properties has been investigated. Mathematical models capable of describing the swelling and release processes from HPMC erodible thin films in different apparatuses have been developed. In particular, we propose a new model for the description of drug transport and release in a Franz cell that accounts for the effect of the unavoidable imperfect mixing of the receptor chamber.https://www.mdpi.com/1999-4923/10/4/222erodible thin filmsHPMCcyclodextrinsfurosemideFranz cellUSP IImillifluidic flow-through deviceerosion |
| spellingShingle | Alessandra Adrover Gabriele Varani Patrizia Paolicelli Stefania Petralito Laura Di Muzio Maria Antonietta Casadei Ingunn Tho Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films Pharmaceutics erodible thin films HPMC cyclodextrins furosemide Franz cell USP II millifluidic flow-through device erosion |
| title | Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films |
| title_full | Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films |
| title_fullStr | Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films |
| title_full_unstemmed | Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films |
| title_short | Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films |
| title_sort | experimental and modeling study of drug release from hpmc based erodible oral thin films |
| topic | erodible thin films HPMC cyclodextrins furosemide Franz cell USP II millifluidic flow-through device erosion |
| url | https://www.mdpi.com/1999-4923/10/4/222 |
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