Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery

Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery

Cathepsin S (CatS) is a secreted cysteine protease that cleaves certain extracellular matrix proteins, regulates antigen presentation in antigen-presenting cells (APC), and promotes M2-type macrophage and dendritic cell polarization. CatS is overexpressed in many solid cancers, and overall, it appea...

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Bibliographic Details
Main Authors: Natalie Fuchs, Mergim Meta, Detlef Schuppan, Lutz Nuhn, Tanja Schirmeister
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
cysteine protease
cysteine cathepsin
nanoparticle
tumor microenvironment
immune suppression
therapy
Online Access:https://www.mdpi.com/2073-4409/9/9/2021

Internet

https://www.mdpi.com/2073-4409/9/9/2021

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