PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis
Phosphatase of regenerating liver (PRL) is frequently overexpressed in various malignant cancers and is known to be a driver of malignancy. Here, we demonstrated that PRL overexpression causes mitotic errors that accompany spindle misorientation and aneuploidy, which are intimately associated with c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japan Society for Cell Biology
2022-11-01
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| Series: | Cell Structure and Function |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/csf/47/2/47_22034/_html/-char/en |