PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis

PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis

Phosphatase of regenerating liver (PRL) is frequently overexpressed in various malignant cancers and is known to be a driver of malignancy. Here, we demonstrated that PRL overexpression causes mitotic errors that accompany spindle misorientation and aneuploidy, which are intimately associated with c...

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Bibliographic Details
Main Authors: Kajung Ryu, Atsushi Yoshida, Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki
Format: Article
Language:English
Published: Japan Society for Cell Biology 2022-11-01
Series:Cell Structure and Function
Subjects:
cancer
ampk
prl
kinetochore
mitotic errors
Online Access:https://www.jstage.jst.go.jp/article/csf/47/2/47_22034/_html/-char/en

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