Single-cell RNA sequencing of murine ankle joints over time reveals distinct transcriptional changes following Borrelia burgdorferi infection

Summary: Lyme disease is caused by the bacterial pathogen Borrelia burgdorferi, which can be readily modeled in laboratory mice. In order to understand the cellular and transcriptional changes that occur during B. burgdorferi infection, we conducted single-cell RNA sequencing (scRNA-seq) of ankle jo...

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Bibliographic Details
Main Authors: Jennifer D. Helble, Michael J. Walsh, Julie E. McCarthy, Neal P. Smith, Alice J. Tirard, Benjamin Y. Arnold, Alexandra-Chloe Villani, Linden T. Hu
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223022940