M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation

M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation

Extracellular histones have been shown to act as DAMPs in a variety of inflammatory diseases. Moreover, they have the ability to induce cell death. In this study, we show that M6229, a low-anticoagulant fraction of unfractionated heparin (UFH), rescues rats that were challenged by continuous infusio...

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Bibliographic Details
Main Authors: Chris P. M. Reutelingsperger, Marion J. Gijbels, Henri Spronk, Rene Van Oerle, Roy Schrijver, Peter Ekhart, Sjef de Kimpe, Gerry A. F. Nicolaes
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
M6229
sepsis
hyperinflammation
extracellular histones
DAMPs
organ injury
Online Access:https://www.mdpi.com/1422-0067/25/3/1376

Internet

https://www.mdpi.com/1422-0067/25/3/1376

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