The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication

The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication

The innate immune response to viruses is formed in part by interferon (IFN)-induced restriction factors, including ISG15, p21, and SAMHD1. IFN production can be blocked by the ISG15-specific protease USP18. HIV-1 has evolved to circumvent host immune surveillance. This mechanism might involve USP18....

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Bibliographic Details
Main Authors: Chaohui Lin, Edmund Osei Kuffour, Taolan Li, Christoph G. W. Gertzen, Jesko Kaiser, Tom Luedde, Renate König, Holger Gohlke, Carsten Münk
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Viruses
Subjects:
ISG15
ISGylation
USP18
p53
STING
HIV-1
Online Access:https://www.mdpi.com/1999-4915/16/4/485

Internet

https://www.mdpi.com/1999-4915/16/4/485

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