Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense

Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense

Tumor hypoxia and oxidative stress reprograms cancer stem cells (CSCs) to a highly aggressive and inflammatory phenotypic state of tumor stemness. Previously, we characterized tumor stemness phenotype in the ATP Binding Cassette Subfamily G Member 2 (ABCG2)–positive migratory side population (SPm) f...

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Bibliographic Details
Main Authors: Seema Bhuyan, Bidisha Pal, Lekhika Pathak, Partha Jyoti Saikia, Shirsajit Mitra, Sukanya Gayan, Reza Bayat Mokhtari, Hong Li, Chilakamarti V. Ramana, Debabrat Baishya, Bikul Das
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Stem cell niche
Tumor stemness
Bacillus calmette guerin
Tumor hypoxia and oxidative stress microenvironment
Cancer Stem Cells (CSCs)
Altruistic Stem Cells (ASCs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.933329/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.933329/full

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