The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation

The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation

The nuclear receptor, REV-ERBα, has a key role in circadian rhythms and requires heme as its ligand. The present study determined whether the heme precursor, 5-aminolevulinic acid (ALA), affects REV-ERBα and its target genes. When exposed to ALA, the human lung diploid cell line, WI-38, exhibited ac...

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Bibliographic Details
Main Authors: Kohei Yamashita, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka, Shun-ichiro Ogura
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
5-Aminolevulinic acid
Circadian rhythms
REV-ERBα
Porphyrin metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000333

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http://www.sciencedirect.com/science/article/pii/S2211546314000333

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