Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving

Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving

<p>Abstract</p> <p>Background</p> <p>Several susceptibility genetic variants for autoimmune diseases have been identified. A subset of these polymorphisms displays an opposite risk profile in different autoimmune conditions. This observation open interesting questions o...

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Bibliographic Details
Main Authors: Comi Giacomo P, Fumagalli Matteo, Pozzoli Uberto, Riva Stefania, Cagliani Rachele, Bresolin Nereo, Clerici Mario, Sironi Manuela
Format: Article
Language:English
Published: BMC 2011-06-01
Series:BMC Evolutionary Biology
Subjects:
autoimmune disease
balancing selection
opposite risk profile
extended MHC region
Online Access:http://www.biomedcentral.com/1471-2148/11/171

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http://www.biomedcentral.com/1471-2148/11/171

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