Polarized desmosome and hemidesmosome shedding via small extracellular vesicles is an early indicator of outer blood‐retina barrier dysfunction

Polarized desmosome and hemidesmosome shedding via small extracellular vesicles is an early indicator of outer blood‐retina barrier dysfunction

Abstract The retinal pigmented epithelium (RPE) constitutes the outer blood‐retinal barrier, enables photoreceptor function of the eye, and is constantly exposed to oxidative stress. As such, dysfunction of the RPE underlies pathology leading to development of age‐related macular degeneration (AMD),...

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Bibliographic Details
Main Authors: Belinda J. Hernandez, Nikolai P. Skiba, Karolina Plössl, Madison Strain, Yutao Liu, Daniel Grigsby, Una Kelly, Martha A. Cady, Vikram Manocha, Arvydas Maminishkis, TeddiJo Watkins, Sheldon S. Miller, Allison Ashley‐Koch, W. Daniel Stamer, Bernhard H. F. Weber, Catherine Bowes Rickman, Mikael Klingeborn
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Journal of Extracellular Biology
Subjects:
age‐related macular degeneration (AMD)
exosome
oxidative stress
polarized
proteomics
retinal pigmented epithelium (RPE)
Online Access:https://doi.org/10.1002/jex2.116

Internet

https://doi.org/10.1002/jex2.116

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