Within-Host Phenotypic Evolution and the Population-Level Control of Chronic Viral Infections by Treatment and Prophylaxis

Chronic viral infections can persist for decades spanning thousands of viral generations, leading to a highly diverse population of viruses with its own complex evolutionary history. We propose an expandable mathematical framework for understanding how the emergence of genetic and phenotypic diversi...

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Bibliographic Details
Main Authors: Dmitry Gromov, Ethan O. Romero-Severson
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Mathematics
Subjects:
Online Access:https://www.mdpi.com/2227-7390/8/9/1500