Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

Cytotoxic CD8 +T lymphocytes (CTLs) are key players of adaptive anti-tumor immunity based on their ability to specifically recognize and destroy tumor cells. Many cancer immunotherapies rely on unleashing CTL function. However, tumors can evade killing through strategies which are not yet fully eluc...

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Bibliographic Details
Main Authors: Ann-Kathrin Herzfeldt, Marta Puig Gamez, Eva Martin, Lukasz Miloslaw Boryn, Praveen Baskaran, Heinrich J Huber, Michael Schuler, John E Park, Lee Kim Swee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
CRISPRa screen
CRISPR KO screen
tumor cell killing
cytotoxic T cells
cancer immunology
ICAM-1
Online Access:https://elifesciences.org/articles/84314

Internet

https://elifesciences.org/articles/84314

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