Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model

Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model

Abstract Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a role for serotonin (5-HT...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Sara Redenšek Trampuž, Sander van Riet, Åsa Nordling, Magnus Ingelman-Sundberg
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	Nature Portfolio 2024-01-01
Saila:	Scientific Reports
Sarrera elektronikoa:	https://doi.org/10.1038/s41598-023-49240-9

Antzeko izenburuak

The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids
nork: Sara Redenšek Trampuž, et al.
Argitaratua: (2023-01-01)

The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model
nork: Sander van Riet, et al.
Argitaratua: (2024-03-01)

Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
nork: Tracey Hurrell, et al.
Argitaratua: (2020-04-01)

Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids
nork: Chris S. Pridgeon, et al.
Argitaratua: (2022-05-01)

Azologization of serotonin 5-HT3 receptor antagonists
nork: Karin Rustler, et al.
Argitaratua: (2019-03-01)

Existence of Brain 5‑HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5‑HT1A Receptor Recognition
nork: Dasiel O. Borroto-Escuela, et al.
Argitaratua: (2017-08-01)

Effects of 5‐HT₃ receptor antagonists on cisplatin‐induced kidney injury
nork: Mitsuhiro Goda, et al.
Argitaratua: (2021-09-01)

How Can 5-HT3 Receptor Antagonists Exert Analgesic Properties?
nork: Abbas Norouzi, et al.
Argitaratua: (2012-04-01)

How Can 5-HT3 Receptor Antagonists Exert Analgesic Properties?
nork: Reza Rahimian, et al.
Argitaratua: (2012-04-01)

Constitutively active 5-HT receptors: An explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not a enteric neurotransmitter ?
nork: Nick eSpencer
Argitaratua: (2015-12-01)

Antiemetic Activity of FK1052, a 5-HT3- and 5-HT4-Receptor Antagonist, in Suncus murinus and Ferrets
nork: Hiroe Nakayama, et al.
Argitaratua: (2005-01-01)

Inverse Agonist Activity of Sarpogrelate, a Selective 5-HT2A-Receptor Antagonist, at the Constitutively Active Human 5-HT2A Receptor
nork: Habib Abul Muntasir, et al.
Argitaratua: (2006-01-01)

5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.
nork: Threlfell, S, et al.
Argitaratua: (2010)

The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585.
nork: Roberts, J, et al.
Argitaratua: (2002)

THE ANTIEMETIC ACTION OF THE NOVEL 5-HT3 RECEPTOR ANTAGONIST L-683,877 IN THE FERRET
nork: Tattersall, F, et al.
Argitaratua: (1990)

ANTAGONIST EFFECT OF MDL-73005EF ON POSTSYNAPTIC 5-HT1A RECEPTORS IN THE RAT
nork: Gartside, S, et al.
Argitaratua: (1990)

Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis.
nork: Boothman, L, et al.
Argitaratua: (2006)

Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists
nork: Heng, Hui Li, et al.
Argitaratua: (2018)

Automated Synthesis of 5-HT1A Receptors Antagonists 11C-WAY-100635
nork: LI Hui-qiang1,2;ZHEN Zhi-fei1;ZHANG Wei-feng1;LIAO Shu-guang1;LI Hong-li3;XU Jun-ling1,2
Argitaratua: (2017-02-01)

3D-QSAR modeling and pharmacophore study of serotonin 5HT-₂A receptors antagonists
nork: Antonijević Mirjana, et al.
Argitaratua: (2017-01-01)

Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome
nork: Itagaki R, et al.
Argitaratua: (2014-03-01)

Combination of Direct DNA Sequencing with Degenerate Primer-Mediated PCR and 5′-/3′-RACE to Screen Novel cDNA Sequences
nork: Che Fang, et al.
Argitaratua: (1997-07-01)

Protocol to generate human liver spheroids to study liver fibrosis induced by metabolic stress
nork: Hyun Young Kim, et al.
Argitaratua: (2024-06-01)

Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.
nork: Corbett, D, et al.
Argitaratua: (2005)

The Human Cytochrome P450 (<it>CYP</it>) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects
nork: Sim Sarah C, et al.
Argitaratua: (2010-04-01)

Intronic polymorphisms of cytochromes P450
nork: Ingelman-Sundberg Magnus, et al.
Argitaratua: (2010-08-01)

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.
nork: Hughes, Z, et al.
Argitaratua: (2007)

Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome.
nork: Humphrey, P, et al.
Argitaratua: (1999)

Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans.
nork: Sharpley, A, et al.
Argitaratua: (1990)

Design of an innovative nanovehicle to enhance brain permeability of a novel 5-HT6 receptor antagonist
nork: María Javiera Alvarez-Figueroa, et al.
Argitaratua: (2024-12-01)

In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer’s Disease
nork: Tijana Bojić, et al.
Argitaratua: (2022-04-01)

Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation
nork: Gonzalo Vera, et al.
Argitaratua: (2016-08-01)

5-HT3-Receptor Antagonist Inhibits Visceral Pain Differently in Chemical and Mechanical Stimuli in Rats
nork: Tomohisa Mori, et al.
Argitaratua: (2004-01-01)

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors.
nork: Gerhard Rammes, et al.
Argitaratua: (2009-08-01)

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models.
nork: Karolina Pytka, et al.
Argitaratua: (2015-01-01)

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT
nork: Tiong Cheng Sia, et al.
Argitaratua: (2013-08-01)

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration.
nork: Castro, E, et al.
Argitaratua: (2003)

A possible role for 5-HT2C receptors in postsynaptic feedback regulation of 5 HT neurones
nork: Raley, J, et al.
Argitaratua: (2006)

Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin(3) (5-HT3) receptor antagonist
nork: Mahesh, R., et al.
Argitaratua: (2004)

The 5-HT2A receptor antagonist M100907 produces antiparkinsonian effects and decreases striatal glutamate
nork: Twum eAnsah, et al.
Argitaratua: (2011-06-01)