Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish

Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish

The pharmacological and toxicological effects of active metabolites of enzymes including cytochrome P450 (CYP) are important. While it has been believed for a long time that thalidomide causes characteristic limb malformation only in rabbits and primates including humans, the involvement of their CY...

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Bibliographic Details
Main Authors: Wenjing Dong, Ippo Akasaka, Akifumi Komiyama, Tatsuro Nakamura, Naohiro Mizoguchi, Tasuku Nawaji, Shinichi Ikushiro, Makoto Kobayashi, Hiroki Teraoka
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
CYP1A1
CYP3A4
CYP3A7
human
teratogenicity
thalidomide
Online Access:https://www.mdpi.com/1424-8247/16/3/368

Internet

https://www.mdpi.com/1424-8247/16/3/368

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