Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR<sup>-/-</sup> mice challenged with the HB29 strain of SFTS viru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/8/4/158 |
| _version_ | 1828345976325144576 |
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| author | Jonna B. Westover Brady T. Hickerson Arnaud J. Van Wettere Brett L. Hurst Jacqueline P. Kurz Ashley Dagley Petra Wülfroth Takashi Komeno Yousuke Furuta Thomas Steiner Brian B. Gowen |
| author_facet | Jonna B. Westover Brady T. Hickerson Arnaud J. Van Wettere Brett L. Hurst Jacqueline P. Kurz Ashley Dagley Petra Wülfroth Takashi Komeno Yousuke Furuta Thomas Steiner Brian B. Gowen |
| author_sort | Jonna B. Westover |
| collection | DOAJ |
| description | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR<sup>-/-</sup> mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR<sup>-/-</sup> mice. |
| first_indexed | 2024-04-14T00:19:25Z |
| format | Article |
| id | doaj.art-d62fed5b2b274856bc5f917b9cf0cdd7 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-14T00:19:25Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d62fed5b2b274856bc5f917b9cf0cdd72022-12-22T02:23:00ZengMDPI AGPathogens2076-08172019-09-018415810.3390/pathogens8040158pathogens8040158Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in MiceJonna B. Westover0Brady T. Hickerson1Arnaud J. Van Wettere2Brett L. Hurst3Jacqueline P. Kurz4Ashley Dagley5Petra Wülfroth6Takashi Komeno7Yousuke Furuta8Thomas Steiner9Brian B. Gowen10Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USAMChE-Trading Handels-GmbH, Vienna 1060, AustriaFUJIFILM Toyama Chemical Co., Ltd., Toyama 930-8508, JapanFUJIFILM Toyama Chemical Co., Ltd., Toyama 930-8508, JapanMChE-Trading Handels-GmbH, Vienna 1060, AustriaDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USASevere fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR<sup>-/-</sup> mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR<sup>-/-</sup> mice.https://www.mdpi.com/2076-0817/8/4/158severe fever with thrombocytopenia syndromeHuaiyangshan banyangvirusviral hemorrhagic fevervascular leakcytokine storm |
| spellingShingle | Jonna B. Westover Brady T. Hickerson Arnaud J. Van Wettere Brett L. Hurst Jacqueline P. Kurz Ashley Dagley Petra Wülfroth Takashi Komeno Yousuke Furuta Thomas Steiner Brian B. Gowen Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice Pathogens severe fever with thrombocytopenia syndrome Huaiyangshan banyangvirus viral hemorrhagic fever vascular leak cytokine storm |
| title | Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice |
| title_full | Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice |
| title_fullStr | Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice |
| title_full_unstemmed | Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice |
| title_short | Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice |
| title_sort | vascular leak and hypercytokinemia associated with severe fever with thrombocytopenia syndrome virus infection in mice |
| topic | severe fever with thrombocytopenia syndrome Huaiyangshan banyangvirus viral hemorrhagic fever vascular leak cytokine storm |
| url | https://www.mdpi.com/2076-0817/8/4/158 |
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