Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells...

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Bibliographic Details
Main Authors: Lidia García-Colmenero, Jéssica González, Juan Sandoval, Yolanda Guillén, Angel Diaz-Lagares, Evelyn Andrades, Arnau Iglesias, Lara Nonell, Ramon Maria Pujol, Anna Bigas, Lluís Espinosa, Fernando Gallardo
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
cutaneous T-cell lymphoma
mycosis fungoides
Sézary syndrome
STAT3 (signal transducer and activator of transcription-3)
JAK/STAT (janus kinase/signal transducer and activator of transcription)
miR-124
Online Access:https://www.mdpi.com/2073-4409/9/12/2692

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https://www.mdpi.com/2073-4409/9/12/2692

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