Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA.

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA.

A major barrier to the elimination of HIV-1 infection is the presence of a pool of long-lived, latently infected CD4+ memory T-cells. The search for treatments to re-activate latent HIV to aid in clearance is hindered by the incomplete understanding of the mechanisms that lead to transcriptional sil...

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Bibliographic Details
Main Authors: Zachary Klase, Venkat S R K Yedavalli, Laurent Houzet, Molly Perkins, Frank Maldarelli, Jason Brenchley, Klaus Strebel, Paul Liu, Kuan-Teh Jeang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3961356?pdf=render

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http://europepmc.org/articles/PMC3961356?pdf=render

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