Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate...

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Bibliographic Details
Main Authors: Natasha KC, L. W. Preston Church, Pouria Riyahi, Sumana Chakravarty, Robert A. Seder, Judith E. Epstein, Kirsten E. Lyke, Benjamin Mordmüller, Peter G. Kremsner, Mahamadou S. Sissoko, Sara Healy, Patrick E. Duffy, Said A. Jongo, Vicente Urbano Nsue Ndong Nchama, Salim Abdulla, Maxmillian Mpina, Sodiomon B. Sirima, Matthew B. Laurens, Laura C. Steinhardt, Martina Oneko, MingLin Li, Tooba Murshedkar, Peter F. Billingsley, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
PfSPZ Vaccine
malaria vaccine
Plasmodium falciparum
PfCSP
antibodies
humoral immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full

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