Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

Abstract Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. In solid tumors, the B7-H3 transmembrane protein is an emerging target that h...

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Bibliographic Details
Main Authors: Dan Li, Ruixue Wang, Tianyuzhou Liang, Hua Ren, Chaelee Park, Chin-Hsien Tai, Weiming Ni, Jing Zhou, Sean Mackay, Elijah Edmondson, Javed Khan, Brad St Croix, Mitchell Ho
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41631-w

Internet

https://doi.org/10.1038/s41467-023-41631-w

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